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The enzyme eNAMPT can fight aging and promote longevity

The enzyme eNAMPT can fight aging and promote longevity

In recent years, nicotinamide adenine dinucleotide (NAD+) biosynthesis and metabolism has emerged as a central topic in the field of aging and longevity research. NAD+ is the most important coenzyme in mammals, but its level decreases with age. Substances contributing to the synthesis of NAD+ can delay age-related functional decline as well as treat age-related diseases. There is already sufficient scientific evidence that supports this claim[1].

In recent years, scientists have been researching on NAD+ biosynthesis and have discovered many key NAD+ intermediates, such as nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR). This June, Professor Shin-ichiro Imai from the U.S. Washington University in St. Louis and his team have found a new anti-aging biologic. eNAMPT is a critical enzyme to maintain NAD+ biosynthesis. Research has proven that increasing circulating eNAMPT levels in mice can improve their health and delay aging. The findings were published on Cell Metaboilsm on June 13 [2]: 

The results indicate that when aged mice consume this enzyme, there is a significant improvement in their physical activity levels, metabolism, brain functions, and an extention in their lifespan. The article points out that eNAMPT can be an effective supplement to fight aging and prolong the lifespan of mice. It is expected that the systematic delivery of extracellular vesicles carrying eNAMPT may become an effective solution to fight aging.

[1] Cantó, Carles, Menzies K , Auwerx J . NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus[J]. Cell Metabolism, 2015, 22(1):31-53.
[2] Mitsukuni Yoshida,Akiko Satoh. Extracellular Vesicle-Contained eNAMPT Delays Aging and Extends Lifespan in Mice[J]. Cell Metabolism,2019.05.015
atin Regulates Insulin Secretion in β Cells as a Systemic NAD Biosynthetic Enzyme[J]. Cell Metabolism, 2007, 6(5):0- 375.v