University of Iowa: Supplementation of NMN may help innate immune system overcome novel coronavirus

Latest research findings published by American medicinal journal The New England Journal of Medicine on May 13 show that cats with SARS-CoV-2 infection will transmit the virus to other cats even while not showing any appreciable symptoms. Virus experts and researchers from the School of Veterinary Medicine at the University of Wisconsin-Madison joined hands to carry out this study. They first aquired the virus, SARS-CoV-2 from an infected human, then had three cats inoculated with the virus. After that, another cat with no previous SARS-CoV-2 infection was cohoused with the inoculated cats to assess whether transmission of the virus by direct contact would occur between them. After three days, nasal and rectal swab specimens were obtained from the cat with no previous SARS-CoV-2 infection - infectious virus has been detected in its nasal swab specimen. These data show the ease of virus transmission between domestic cats. They also show that cats may transmit the virus to other cats while not showing any appreciable symptoms. The researchers thus speculate that cats may be a silent intermediate host of SARS-CoV-2; there may be a potential chain of human–cat–human transmission.

Scientists from different countries have pointed out time and again that exogenous supplementation of NAD+ will become a feasibile and effective cure and prevention to Covid-19. Theoretically, novel coronavirus (SARS-CoV-2) infection will activate polyadenosine diphosphate ribose polymerases (PARPs) in host cells, accelerate NAD+ consumption, and cause various physiological problems. Therefore, supplementation of NAD+ can alleviate or even treat a variety of Covid-19 symptoms.

Finally, on April 19, 2020, Brenner and his team from the University of Iowa completed and announced their experimental results on the relationship between NAD+ and the novel coronavirus. They discovered that exogenous supplementation of NAD+ may be the key to help the innate immune system overcome the novel coronavirus.

The experimental data were first published on the scientific research website BioRxiv on April 19, 2020.

When the innate immune system detects the novel coronavirus that has entered the body, it will stimulate a series of immune responses to protect itself. One of the most critical measures is the large-scale transcription of PARPs, which inhibits the replication of the virus at the expense of NAD+.

Brenner and his team's in vitro experimental results basically match their theoretical predictions. After the animal's bronchial epithelial cells are infected with the novel coronavirus, the transcription level of PARPs indeed increases significantly.

Brenner and his team believe that supplementing NAD+ precursors may be the best way to raise NAD+ levels and PARPs activity under the Covid-19 epidemic. On one hand, according to existing data, the metabolic pathways of the two mainstream NAD+ precursors, NMN and NR, have not yet been affected by Covid-19 infection, thus the effectiveness of the conversion is guaranteed.